Orbitrap Excedion Pro Mass Spectrometers

Description

Welcome to the future of mass spectrometry. Enhance your research and achieve groundbreaking discoveries with Thermo Scientific Orbitrap Excedion Pro Hybrid Mass Spectrometers, the next generation of mass spectrometry.
With enhanced sensitivity and dynamic range, the standard model is ideal for advanced applications in metabolomics, lipidomics, proteomics, translational research, and structural biology while the BioPharma Edition is tailored for the demanding requirements of the biopharmaceutical industry. Both models offer innovative features that surpass the capabilities of the previous Thermo Scientific Orbitrap Exploris 480 Mass Spectrometer.

Explore the model that best suits your needs and unlock the full potential of your analytical workflows.

The Orbitrap Excedion Pro BioPharma Mass Spectrometer ensures comprehensive characterization by detecting and quantifying impurities and modifications, performing accurate quantitative analysis, and enhancing top-down, middle-down, and bottom-up capabilities. It streamlines workflows for rapid, high-throughput analysis, significantly reducing time-to-results and increasing productivity.

Tryptic digest peptide map
Click image to enlarge
UHPLC-HRAM-MS-ddMS2 analysis of NISTmAb tryptic digest peptide mapping experiment, EThcD unambiguously identified the two leucine residues (loss of 43Da from z9 and z12 fragments) and one isoleucine residue (loss of 29Da from z6 fragments) in this 13-amino acids doubly charged peptide with complete sequence coverage. Zoom-in insets show high mass accuracy (<5ppm) achieved for the signature fragments.

ETD isoaspartic acid
Click image to enlarge
Signature fragments (c+57 and z-57) generated by ETD distinguish isoaspartic acid from aspartic acid.b: In a UHPLC-HRAM-MS-ddMS2 analysis of NISTmAb tryptic digest peptide mapping experiment, EThcD achieved high sequence coverage and unambiguously identified isoaspartic acid in a 23-amino acid triply charged deamidated peptide present at a low abundance level (0.18%) with high confidence. The zoom-in insets showed the high mass accuracy (<8 ppm) achieved for both signature fragments (z6-57 and c17+57).