Orbitrap Astral Zoom Mass Spectrometer

Description

Realize a universe of possibilities
Accelerate discoveries forward with increased flexibility to deliver faster throughput, deeper coverage, higher sensitivity, and accurate and precise quantitation across more applications. The Thermo Scientific Orbitrap Astral Zoom Mass Spectrometer is designed to explore more molecular space to achieve the next generation of breakthroughs in Omics and Biopharma research with faster scan rates, improved sensitivity, novel acquisition methods including hybrid DIA and TMT HR mode, and greater flexibility. Turn ideas into discoveries to advance science exponentially and drive clinical research forward into interventions that improve outcomes.

Enhanced instrument architecture
The Thermo Scientific Orbitrap Astral Zoom Mass Spectrometer is designed to achieve the next generation of breakthroughs with upgraded hardware and software capabilities to deliver increased flexibility, faster throughput, deeper coverage, higher sensitivity, and accurate and precise quantitation. Leverage the benefits of parallelized acquisition with two high-resolution accurate mass analyzers (HRAM) enabled by the unique instrument architecture of the platform featuring the Orbitrap and Astral analyzers.

Orbitrap Astral Zoom Mass Spectrometer architecture
Orbitrap Astral Zoom Mass Spectrometer architecture
Fast ion filter for pre-filtering of ions
Bent trap for parallelized pre-accumulation of ions
High-speed quadrupole for improved precursor isolation switching
Enhanced dynamic range mode to increase Orbitrap analyzer full scan dynamic range
Faster stepped collision energy to enable rapid acquisition of richer fragmentation spectra
Faster ion processor to enable scan rates up to 270 Hz
Relay prism to increase Astral analyzer resolution up to 100,000 at m/z 138 with TMT HR mode
Low-input mode to increase the probability of single-ion detection for higher sensitivity
Enhanced spectral processing to improve data quality and peak resolution
Hybrid DIA method support for the intelligent acquisition of targeted and untargeted data in a single injection
Available Biopharma option to enable top-down and middle-down Astral analyzer MS2 experiments along with an extended Orbitrap analyzer mass range of 40–8,000 and improved pressure regulation

Key feature highlights
Pre-accumulation
The Orbitrap Astral Zoom Mass Spectrometer features additional automatic gain controlled (AGC) parallelization of injection time before the quadrupole through the addition of the fast ion filter and bent trap. This pre-accumulation provides longer effective injection times without a loss in duty cycle, increasing the number of ions by up to 50% per scan and enabling the acquisition of high-quality analytical spectra at scan rates up to 270 Hz.